Description

Title Constructing Disease-centric Knowledge Graphs: a case study for depression
Abstract A large number of medical knowledge sources have been converted to knowledge graphs, covering everything from drugs to trials and from vocabularies to gene-disease associations. Such knowledge graphs are typically generic, covering very large areas of medicine (e.g. all of internal medicine, or arbitrary drugs, arbitrary trials, etc). Such knowledge graphs become prohibitively large, hampering both efficiency for machines and usability for people. In this talk we show how we used multiple large knowledge sources to construct a much smaller knowledge graph that is focussed on single disease (in our case major depression disorder). Such a disease-centric knowledge-graph makes it more convenient for doctors (in our case psychiatric doctors) to explore the relationship among various knowledge resources and to answer realistic clinical queries.